The optimization of the MS-SQL protocol is only supports the MS-SQL 2000 protocol. The reason for this is because the encrypted login session for later versions of the MS-SQL protocol is not decodable and thus is the optimization service not able to identify the database to connect to.
Before enabling this feature please contact Riverbed Professional Services for an investigation in the improvements of this data.
Since RiOS 8.5 the MS-SQL latency optimization feature has been removed from the GUI.